ABSTRACT
Natural killer cytolitic activity, the basis of cancer immunotherapy that uses cytolytic cells, may be impaired in cancer. The aim of this work was to study in vitro the natural killer cytolitic activity and its response to the immunomodulators interleukin-2 interferon and phytohemagglutinin stimulated lymphocyte proliferation in a group of 9 patients with renal cell cancer and 6 with prostatic cancer. The results were compared with those of 20 normal volunteers. Twelve patients were operated and were studied twice 48 h and 14 days after surgery. Natural killer cytolitic activity was significantly lower in renal cell and prostatic cancer patients than controls (3.3 ñ 1.6, 4.9 ñ 2.2 and 20.6 ñ 3.7 per cent of specific lysis respectively). This activity was not modified in cancer patients by interleukin-2 50 Ul/ml or interferon 3000 Ul/ml and did not differ in the two postoperative pèriods. Phytohemagglutinin stimulated lymphocyte proliferation was also lower in cancer patients, compared to controls (stimulation index of 18 ñ 3 and 26.5 ñ 5 respectively). It is concluded that these patients have a low immunological level and this study is the first step towards an immunological characterization of cancer patients that are candidate to adoptive immunotherapy
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Prostatic Neoplasms/immunology , Kidney Neoplasms/immunology , Killer Cells, Natural/physiology , Phytohemagglutinins/immunology , Cell Separation/methods , Cytotoxicity Tests, Immunologic/methodsABSTRACT
Se revisa la histología de 44 pacientes con diagnóstico de adenocarcinoma renal; analizándose las características histológicas según el tipo de células presentes, la morfología del núcleo y la organización celular. La presencia de células, fusadas y las morfología nuclear demostraron cierto valor pronóstico, no así la organización celular
Subject(s)
Humans , Carcinoma, Renal Cell/pathology , Sarcoma/pathology , Carcinoma, Renal Cell/surgery , Carcinoma, Renal Cell/diagnosis , Disease-Free Survival , Nephrectomy , Prognosis , Histological Techniques/methodsABSTRACT
La ecotomografía escrotal, es una herramienta de utilidad en el diagnóstico diferencial de las masas escrotales. Para establecer su correlación con la clínica seleccionamos 99 pacientes sometidos a este procedimiento y los cotejamos con los hallazgos de la anatomía patológica y con un adecuado seguimiento clínico. Obtuvimos una excelente correlación para las neoplasias testiculares, para la patología benigna testicular, y fue útil además en la búsqueda de testículos ectópicos. No resultó de utilidad para determinar características histológicas de los tumores, así como tampoco la recomendamos en los traumatismos testiculares
Subject(s)
Humans , Male , Adult , Scrotum , Genital Neoplasms, Male , Diagnosis, Differential , Scrotum/pathology , Genital Neoplasms, Male , Retrospective StudiesABSTRACT
Se presentan 2 casos de uraco persistente en el adulto. Un quiste y un uraco abierto a ombligo. Se discute la etiopatogenia. Ambos fueron resecados con éxito